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Common Origin And Developmental Dependence On C-ret Of

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• Durbec PL(1), Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V
• Author information: (1)Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK
• c-ret encodes a tyrosine kinase receptor that is necessary for normal development of the mammalian enteric nervous system.

C‐cell Hyperplasia, Pheochromocytoma And Sympathoadrenal

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• Durbec PL, Larsson‐Blomberg LB, Schuchardt A, Costantini F and Pachnis V (1996) Common origin and developmental dependence on c‐ret of subsets of enteric and sympathetic neuroblasts
• CAS PubMed Web of Science® Google Scholar; Edery P et al
• (1994) Mutations of the RET proto‐oncogene in Hirschsprung's disease.

Category:Blomberg (surname)

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• This page was last edited on 26 November 2019, at 19:48
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Hirschsprung's Disease: Genetic Mutations In Mice And Men

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V
• Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts

Hirschsprung’s Disease: Genetic Mutations In Mice And Men

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Hirschsprung’s disease is a neuronal dysplasia of the hindgut, characterised by a loss of neurones, which affects about 1 in 5000 live births.[1][1] Genetic factors have been implicated in the aetiology of this disease in about 20% of cases and a dominant pattern of inheritance has been revealed in several families.[2][2] ,[3][3]The pathogenesis of the aganglionosis is often attributed to a

Expression Of Leukaemia Inhibitory Factor During The

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• Leukaemia inhibitory factor (LIF) is a neuropoietic cytokine, which promotes the development of enteric neurons in vitro, particularly when administered together with neurotrophin-3 (NT-3)
• The purpose of this study was to map the LIF immunoreactivity in the human enteric nervous system in foetuses, children, adults, and in patients with Hirschsprung's disease.

GDNF Family Receptors In The Embryonic And Postnatal Rat

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• Gfra1 mRNA expression in the developing rat heart was first detectable at E12 (33 somites; Fig
• Gfra1 expression was seen in the mesenchymal endocardial cushion cells around the AV canal and in some cells of the outflow tract (Fig
• Endothelial cells lacked Gfra1 expression, whereas Gfra2 mRNA was seen in many endocardial endothelial cells throughout the …

Idiopathic Slow-transit Constipation Is Not Associated

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• PURPOSE: Idiopathic slow-transit constipation is a severe disorder of unknown cause
• The onset in early childhood and history of constipation or Hirschsprung's disease in close family relatives suggest that slow-transit constipation could have a genetic basis
• Several germline mutations have been described in Hirschsprung's disease, including mutations ofRET and the gene encoding its ligand

(PDF) Distribution Of Glial Cell Line-derived Neurotrophic

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, et al: Com- glial cell line-derived neurotrophic factor (GDNF) mRNA in rat
• Brain mon origin and developmental dependence on c-ret of subsets of enteric Res Dev Brain Res 85:80-88,1995 and sympathetic neuroblasts.

Molecular Fingerprinting Delineates Progenitor Populations

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• (A) At 36 hpf, we imaged migrating progenitors in four alternate sections at the wave front (w).At 54 (B), 60 (C), and 84 (D) hpf, we analyzed three regions: an anterior region (a) defined by the most anterior appearance of phox2bb:EGFP + progenitor cells around the intestinal epithelium; a posterior region (p) defined to be the last section with phox2bb:EGFP + enteric

Neuronal Differentiation In Schwann Cell Lineage Underlies

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• Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V (1996) Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
• Development 122: 349 – 358, pmid: 8565847.

Additive Effects Of Gene Regulatory Variants In

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, et al
• Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
• de Graaff E, Srinivas S, Kilkenny C, et al
• Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis.

Dual Origin Of Enteric Neurons In Vagal Schwann Cell

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The enteric nervous system of vertebrates arises mostly from a rostral portion of the neural crest, encapsulated by the term “vagal.” We show that the “vagal crest” is in fact a juxtaposition of two completely different types of cells: Schwann cell precursors associated with the vagus nerve, which provide esophageal neurons, and the rostral-most trunk crest, which also forms

A Novel Pathogenesis Of Megacolon In Ncx/Hox11L.1

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V
• Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts

Differential Requirement Of Tyr1062 Multidocking Site By

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• The receptor tyrosine kinase RET is alternatively spliced to yield two main isoforms, RET9 and RET51, which differ in their carboxyl terminal
• Activated RET induces different biological responses

Pharmaceutical Pricing In Croatia: A Comparison Of

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• Sjoborg B, Backstrom T, Arvidsson LB, Andersen-Karlsson E, Blomberg LB, Eiermann B, et al
• Design and implementation of a point-of-care computerized system for drug therapy in Stockholm metropolitan health region—Bridging the gap between knowledge and practice

Ganglioneuromas And Renal Anomalies Are Induced By

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costan-tini F and Pachnis V
• 1996 Development 122: 349–358
• Edery P, Eng C, Munnich A and Lyonnet S

Sarasota Herald Tribune Archives, Jun 18, 1972, P. 27

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• Read Sarasota Herald Tribune Newspaper Archives, Jun 18, 1972, p
• 27 with family history and genealogy records from sarasota, florida 1938-1978.

SP Proteins And PHOX2B Regulate The Expression Of The

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• Phox2a is a vertebrate homeodomain transcription factor that is involved in the specification of the autonomic nervous system
• We have isolated the 5′ regulatory region of the human Phox2a gene and studied the transcriptional mechanisms underlying its expression
• We first identified the minimal gene promoter by means of molecular and functional criteria and demonstrated that its activity

Holtzman Is Felled In Eighth After Holding Yanks To 1 Hit

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• This is a digitized version of an article from The Times’s print archive, before the start of online publication in 1996
• To preserve these articles as they originally appeared, The Times does

Neuropeptide Y Immunoreactivity In Cutaneous Sympathetic

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V
• Development, (1):349-358 MED: 8565847 Development of the cholinergic neurotransmitter phenotype in postganglionic sympathetic neurons
• Cell Tissue Res., (3):339-361 MED: 10460483 The peripheral innervation of the vessels of the external ear of the

Sympathetic Neuron Survival And TrkA Expression In NT3

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• Durbec PL, Larsson‐Blomberg LB, Schuchardt A, Costantini F and Pachnis V (1996) Common origin and developmental dependence on c‐ret of subsets of enteric and sympathetic neuroblasts
• CAS PubMed Web of Science® Google Scholar

Development Of Interstitial Cells Of Cajal In The Human

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• Sagittal sections of a human embryo at 8 weeks of development (two very close sections)
• (A) PGP9,5—immunohistochemistry; the inceptions of MP ganglia are numerous in the posterior wall (arrows) and slightly less abundant in the anterior of the primitive oesophagus (arrow heads).(B) c‐kit immunohistochemistry; c‐kit positive cells in the posterior (arrows) and anterior wall of …

Genes And Lineages In The Formation Of The Enteric Nervous

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V: Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
• Le Douarin NM, Renaud D, Teillet M-A, LeDouarin GH: Cholinergic differentiation of presumptive edrenergic neuroblasts in interspecific

Development Of Enteric Neuron Diversity

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Neuronal diversity in the adult enteric nervous system (ENS) The ENS is composed of a complex network of neurons plus an equal or higher number of enteric glial cells [1, 2].Enteric neurons form complex circuits that regulate or control a variety of gut functions including motility, secretion, vascular tone and release of hormones.

(PDF) Molecular Control Of Neural Crest Formation

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Constantini F, growth factor restricts mammalian neural crest stem cells to a Pachnis V: Common origin and dependence on c-ret of subsets of glial fate
• enteric and sympathetic neuroblasts

The Role Of GDNF Family Ligand Signalling In The

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• The diversity of neurons in sympathetic ganglia and dorsal root ganglia (DRG) provides intriguing systems for the analysis of neuronal differentiation
• Cell surface receptors for the GDNF family ligands (GFLs) glial cell-line-derived neurotrophic factor (GDNF), neurturin and artemin, are expressed in subpopulations of these neurons prompting the question regarding their involvement in neuronal

Common Origin And Developmental Dependence On C-ret Of

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• c-ret encodes a tyrosine kinase receptor that is necessary for normal development of the mammalian enteric nervous system
• Germline mutations in c-ret lead to congenital megacolon in humans, while a loss-of-function allele (ret.k-) causes intestinal aganglionosis in mice.Here we examine in detail the function of c-ret during neurogenesis, as well as the lineage relationships among cell

Enteric Nervous System: Development And Developmental

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This review, which is presented in two parts, summarizes and synthesizes current views on the genetic, molecular, and cell biological underpinnings of the early embryonic phases of enteric nervous system (ENS) formation and its defects.

Multiple Endocrine Neoplasia Type 2 AndRET: From Neoplasia

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• Multiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome characterised by medullary thyroid carcinoma (MTC), with or without phaeochromocytoma and hyperparathyroidism
• MEN 2 is unusual among cancer syndromes as it is caused by activation of a cellular oncogene, RET
• Germline mutations in the gene encoding the RET receptor tyrosine kinase are found in the vast majority of

A's Top Yanks, 4‐2, On Bando's Slam

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• This is a digitized version of an article from The Times’s print archive, before the start of online publication in 1996
• To preserve these articles as they originally appeared, The Times does

Development Of The Mammalian Enteric Nervous System

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• Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V: Common origin and developmental dependence on 326 Genetics of disease c-ret of subsets of enteric and sympathetic neuroblasts
• notype that is essentially identical to that of GDNF- and RET-deficient mice

Assessment Of EPrescription Quality: An Observational

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• The introduction of electronic transfer of prescriptions (ETP) or ePrescriptions in ambulatory health care has been suggested to have a positive impact on the prescribing and dispensing processes
• Thereby, implying that ePrescribing can improve safety, quality, efficiency, and cost-effectiveness
• In December 2007, 68% of all new prescriptions were transferred electronically in Sweden.

Interface Management Of Pharmacotherapy. Joint Hospital

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Read "Interface management of pharmacotherapy. Joint hospital and primary care drug recommendations, European Journal of Clinical Pharmacology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Early Death Of Neural Crest Cells Is Responsible For Total

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• Intestinal aganglionosis results from homologous genetic defects in humans and mice, including mutations of Sox10, which encodes a transcription factor expressed in neural crest cells

Enteric Nervous System Development: Migration

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• Durbec PL , Larsson-Blomberg LB , Schuchardt A , Costantini F , Pachnis V
• Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
• Development 122 : 349–358, 1996 .

(PDF) Huang EJ, Reichardt LF. Neurotrophins: Roles In

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• Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems
• Neurotrophins activate two different classes of receptors, the Trk family of receptor tyrosine kinases

Are Interstitial Cells Of Cajal Plurifunction Cells In The

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The proposed functions of the interstitial cells of Cajal (ICC) are to 1) pace the slow waves and regulate their propagation, 2) mediate enteric neuronal signals to smooth muscle cells, and 3) act