Isletstudy.org

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Website: Isletstudy.org
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City: Iowa City
Postal Code: 52242
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Longitude: -91.544700622559
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Clinical Islet Transplantation Study (CIT)

Isletstudy.org   DA: 14 PA: 14 MOZ Rank: 28

Islet transplantation as a therapy for T1D has been an important focus of governmental funding, and significant research progress has occurred in recent years. Islet transplantation is a procedure performed on select patients with Type-1 diabetes to replace insulin-producing cells destroyed by the disease and restore normal blood sugar levels.

CLINICAL ISLET TRANSPLANTATION (CIT) …

Isletstudy.org   DA: 18 PA: 50 MOZ Rank: 69

Clinical Islet Transplantation (CIT) CONFIDENTIAL Page 1 of 123 Protocol CIT-07 Islet Transplantation in Type 1 Diabetes Version 8.0 (20 August 2012)

Islet Transplantation In Type 1 Diabetes

Clinicaltrials.gov   DA: 18 PA: 21 MOZ Rank: 41

  • The purpose of this study is to determine the safety and effectiveness of islet transplantation, combined with immunosuppressive medications, for treating type 1 diabetes in individuals experiencing hypoglycemia unawareness and severe hypoglycemic episodes
  • Type 1 diabetes is commonly treated with the administration of insulin, either by

Studies Test New Approaches To Islet …

Nih.gov   DA: 11 PA: 50 MOZ Rank: 64

  • Researchers from 11 medical centers in the United States, Canada, Sweden, and Norway have begun testing new approaches to transplanting clusters of insulin-producing islets in adults with difficult-to-control type 1 diabetes
  • The clinical studies, funded by the National Institutes of Health (NIH), will determine whether changes to current methods of islet transplantation lead to improved, long

Islet Preparation Purity Is Overestimated, And …

Ncbi.nlm.nih.gov   DA: 20 PA: 25 MOZ Rank: 49

  • After standard islet isolation and purification, pure islet fractions were placed at 37°C with 5% CO 2 for 12-24 hours and subsequently moved to 22°C,whereas less pure fractions were cultured at 22°C for the entire duration
  • Culture density was targeted at a range of 100-200 islet equivalents (IEQ)/cm 2 adjusted for purity. Islets were assessed for purity (dithizone staining

PROTOCOL CIT-01: O R M -C S E S

Repository.niddk.nih.gov   DA: 24 PA: 46 MOZ Rank: 75

  • documents are available on a web-site maintained by the Data Coordinating Center, www.isletstudy.org 1.2
  • National Institute of Health (NIH) NIH is responsible for all scientific aspects of the study
  • The Institutes (NIAID and NIDDK) are

Improvement In β-Cell Secretory Capacity After …

Diabetes.diabetesjournals.org   DA: 29 PA: 18 MOZ Rank: 53

  • The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, and intensive insulin therapy with the same low-dose tacrolimus and sirolimus maintenance immunosuppression as in the Edmonton protocol
  • To determine whether CIT07 improves engrafted islet β-cell mass, our center measured β-cell secretory capacity from

Ninth Annual Report

Citregistry.org   DA: 15 PA: 28 MOZ Rank: 50

  • www.isletstudy.org; www.citisletstudy.org)
  • The US Food and Drug Administration and the National Institute of Allergy and Infectious Diseases (NIAID) lend continuing support and advice
  • The report has been prepared by staff of The Emmes Corporation under the leadership of the CITR

Engineering Islets From Stem Cells For Advanced …

Nature.com   DA: 14 PA: 28 MOZ Rank: 50

  • Diabetes mellitus is a metabolic disorder that affects more than 460 million people worldwide
  • Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas type 2 …

(PDF) Improvement In -Cell Secretory Capacity …

Academia.edu   DA: 16 PA: 50 MOZ Rank: 75

  • ORIGINAL ARTICLE Improvement in b-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol Michael R
  • Rickels,1 Chengyang Liu,2 Richard D
  • Soleimanpour,1 Kumar Vivek,2 Malek Kamoun,4 Zaw Min,2 Eileen Markmann,2 Maral Palangian,2 Cornelia Dalton-Bakes,1 Carissa Fuller,1 Allen J

Liberase MTF C/T, GMP Grade Leading Results For …

Custombiotech.roche.com   DA: 23 PA: 50 MOZ Rank: 83

  • Liberase MTF C/T is a highly purified blend of Collagenase I/II and Thermolysin, developed for pancreatic islet cell isolation

Improvement In Insulin Sensitivity After Human Islet

Ncbi.nlm.nih.gov   DA: 20 PA: 25 MOZ Rank: 56

  • Insulin sensitivity is impaired in type 1 diabetes (T1D) (1, 2), an effect attributable to frequent periods of sustained hyperglycemia with accompanying increases in free fatty acids (FFAs) ().Intrahepatic islet transplantation can correct the hyperglycemia of T1D and restore normal FFA metabolism (4–6) and so may improve insulin sensitivity.
  • However, current glucocorticoid-free

Phase 3 Trial Of Transplantation Of Human Islets In …

Care.diabetesjournals.org   DA: 25 PA: 35 MOZ Rank: 72

  • RESEARCH DESIGN AND METHODS Study Oversight This independently monitored study was performed in accordance with U.S
  • FDA regulations and Good Clinical Practice Guidelines under a U.S
  • Investigational New Drug application for purified human pancreatic islets (PHPI)
  • Clinical and manufacturing protocols, end points,

Tenth Annual Report

Citregistry.org   DA: 15 PA: 25 MOZ Rank: 53

  • www.isletstudy.org; www.citisletstudy.org)
  • The report has been prepared by staff of The Emmes Corporation under the leadership of the CITR Publications and Presentations Committee chaired by Dr
  • Michael Rickels, and CITR Coordinating Center Principal Investigator, Ms

Phase 3 Trial Of Transplantation Of Human Islets In …

Care.diabetesjournals.org   DA: 25 PA: 18 MOZ Rank: 57

  • OBJECTIVE Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D)
  • Current therapies are effective in preventing SHEs in 50–80% of patients with IAH and SHEs, leaving a substantial number of patients at risk
  • We evaluated the effectiveness and safety of a standardized human pancreatic

Isletstudy.org

Urlbacklinks.com   DA: 20 PA: 20 MOZ Rank: 55

  • Provided by Alexa ranking, isletstudy.org has ranked N/A in N/A and 1,281,739 on the world.isletstudy.org reaches roughly 2,439 users per day and delivers about 73,163 users each month
  • The domain isletstudy.org uses a Commercial suffix and it's server(s) are located in N/A with the IP number 128.255.166.109 and it is a .org
  • Islet transplantation as a therapy for T1D has been …

Islet Transplantation In The Subcutaneous Space …

Nature.com   DA: 14 PA: 27 MOZ Rank: 57

Pancreatic islet transplantation is the most effective β-cell replacement therapy available to achieve precise glycaemic control in patients with type 1 diabetes 4.Current clinical islet

RFA-DK-12-501: Limited Competition: Continuation Of …

Grants.nih.gov   DA: 14 PA: 42 MOZ Rank: 73

  • NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Limited Competition: Continuation of the Clinical Islet Transplantation (CIT) Consortium Data Coordinating Center (U01) RFA-DK-12-501

Stopping Type 1 Diabetes

Medscape.com   DA: 16 PA: 21 MOZ Rank: 55

T1DGC Type 1 Diabetes Genetics Consortium T1DGC was established with the primary goal of organizing international efforts to identify genes that determine an individual'srisk of type 1 …

Diabetes‐free Survival After Extended Distal

Onlinelibrary.wiley.com   DA: 23 PA: 27 MOZ Rank: 69

  • Islet autotransplant (IAT) has initially been performed to prevent surgical diabetes after total or subtotal pancreatectomy for chronic pancreatitis
  • 1, 2 Additional indications for IAT other than chronic pancreatitis are still controversial 3 and the experience has been limited to small case series
  • 4-8 One particularly attractive use for IAT is after extended distal

Domain Health Check: Isletstudy.net Uptime.com

Uptime.com   DA: 10 PA: 15 MOZ Rank: 45

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Stopping Type 1 Diabetes

Medscape.com   DA: 16 PA: 19 MOZ Rank: 56

  • Progression of the type 1 diabetes disease process
  • This is a cellular autoimmune process occurring in individuals with a genetic …

Validity Of Animal Models Of Type 1 Diabetes, And

Sciencedirect.com   DA: 21 PA: 38 MOZ Rank: 81

  • According to the Diabetes Atlas (International Diabetes Federation, 2013), 8–10% of the world population between 20 and 80 years suffers from diabetes.This amounts to 380 million people in 2013, growing to 590 million in 2035
  • In this population, 5–10% are type 1 diabetic (T1D) patients, i.e., the world population of T1D patients in 2013 is estimated at

Studies Test New Approaches To Islet Transplantation

Diabetesresearch.org   DA: 24 PA: 50 MOZ Rank: 97

  • Studies Test New Approaches to Islet Transplantation
  • Miami, FL (May 2008) -- Researchers from 11 medical centers in the United States, Canada, Sweden, and Norway have begun testing new approaches to transplanting clusters of insulin-producing islet cells in adults with difficult-to-control type 1 diabetes.

Retrospective Cohort Study Comparing The Risk Of …

Bmcinfectdis.biomedcentral.com   DA: 30 PA: 35 MOZ Rank: 89

  • To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults
  • This retrospective cohort study combined data from two large US- based hospital electronic medical record databases
  • Severe hepatotoxicity was a Grade ≥ 3 liver function test (LFT) post-echinocandin initiation.

Regulatory Aspects Of Clinical Xenotransplantation

Sciencedirect.com   DA: 21 PA: 38 MOZ Rank: 84

The guidelines for xenotransplant products, and the regulations on which these are based, address a number of aspects regarding both the porcine donor and the human recipient ().The source herd should be accommodated in a biosecure barrier facility ensuring a designated pathogen-free (DPF) status: this status is in a pragmatic way defined as the absence of not only infectious …

Ctcae V5 Anemia Common Terminology Criteria For …

Link-de.com   DA: 15 PA: 23 MOZ Rank: 64

  • Common Terminology Criteria for Adverse Events (CTCAE) cancer.gov
  • https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8

RFA-DK-09-501: Limited Competition: Continuation Of …

Grants.nih.gov   DA: 14 PA: 42 MOZ Rank: 83

  • The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID) invite applications for Clinical Centers (CC) and a Data Coordinating Center (DCC) to participate in a consortium of investigators and institutions that will continue the implementation of established

Autologous Pancreatic Islet Transplantation In Human …

Diabetes.diabetesjournals.org   DA: 29 PA: 19 MOZ Rank: 76

  • The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being ideal
  • We recently have shown in mice that the bone marrow (BM) may be a valid alternative to the liver, and here we report a pilot study to test feasibility and safety of BM as a site for islet transplantation in humans
  • Four patients who developed diabetes after total pancreatectomy

Biennial Report Of The Director, NIH, FY 2006 & 2007 …

Report.nih.gov   DA: 14 PA: 50 MOZ Rank: 93

  • For more information, see www.isletstudy.org (E) (NIDDK, NIAID) Translational Research for the Prevention and Control of Diabetes and Obesity: NIH is supporting research projects to explore ways to bring knowledge from successful clinical research into medical practice and community settings
  • Studies are seeking to develop effective

Autologous Islet Transplantation In Patients …

Onlinelibrary.wiley.com   DA: 23 PA: 26 MOZ Rank: 79

  • Autologous Islet Transplantation in Patients Requiring Pancreatectomy: A Broader Spectrum of Indications Beyond Chronic Pancreatitis G

Autologous Pancreatic Islet Transplantation In Human …

Europepmc.org   DA: 13 PA: 20 MOZ Rank: 64

  • The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being ideal
  • We recently have shown in mice that the bone marrow (BM) may be a valid alternative to the liver, and here we report a pilot study to test feasibility and safety …

Ctcae V5 Anemia Common Terminology Criteria For …

Keyword-rank.com   DA: 20 PA: 23 MOZ Rank: 75

  • Aug 13, 2020 · By using World Health Organization (WHO) criteria and the CTCAE (v5.0) grading system for anemia, a definition for cancer-associated anemia was established: grade 1 anemia was defined as Hb ≤11.9 g/dL for women with cancer and Hb ≤12.9 g/dL for men with cancer
  • Severity of anemia increases with increasing grade up to grade 5

Studies Test New Approaches To Islet Transpla EurekAlert!

Eurekalert.org   DA: 18 PA: 21 MOZ Rank: 72

Researchers from 11 medical centers in the United States, Canada, Sweden, and Norway have begun testing new approaches to transplanting clusters of insulin-producing islets in adults with

IS ISLET-CELL TRANSPLANTATION POSITIONED TO …

Householdmedicalmanual.wordpress.com   DA: 36 PA: 50 MOZ Rank: 16

  • Can T1DM be cured by application of allogeneic pancreatic allo-transplantation? Is the liver a sub-optimal transplantation site for intra-portally transplanted human islet-allografts? Are there other recipient sites for transplanted islets? Is the procedure of islet–cell transplantation in diabetics still viewed as

Completion Of The First FDA Phase 3 Multicenter Trial Of

Isct-cytotherapy.org   DA: 24 PA: 39 MOZ Rank: 98

  • The Clinical Islet Transplantation (CIT) Consortium was established in 2005 by the NIH with the goals of advancing CIT through clinical trials, developing standard procedures for islet manufacturing and patient care, and generating the information needed for FDA licensure for islet products
  • In this FDA Phase 3 single-arm study (NCT #00434811), 8 centers and the CIT Data Coordinating Center

S14 Oral Abstracts

Isct-cytotherapy.org   DA: 24 PA: 34 MOZ Rank: 94

  • and MSC+CXCR4 group demonstrated improvement in pulmonary functions tests and oxygen requirement compared to the control group
  • Conclusion: Targeted MSC therapy with CXCR4 demonstrates safety

Randomised, Prospective, Medico-economic …

Bmjopen.bmj.com   DA: 15 PA: 20 MOZ Rank: 72

  • Introduction Islet transplantation may be an appropriate treatment option for patients with severely unstable type 1 diabetes experiencing major glucose variability with severe hypoglycaemia despite intensive insulin therapy
  • Few data are available on the costs associated with islet transplantation in relation to its benefits
  • The STABILOT study proposes to assess the economic impact of islet

Improvement In Insulin Sensitivity After Human Islet

Academic.oup.com   DA: 16 PA: 33 MOZ Rank: 87

  • Islet transplantation can improve metabolic control for type 1 diabetes (T1D), an effect anticipated to improve insulin sensitivity

CiteSeerX — University

Citeseerx.ist.psu.edu   DA: 21 PA: 16 MOZ Rank: 76

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): null

Insulin Sensitivity Index In Type 1 Diabetes And …

Journals.physiology.org   DA: 23 PA: 31 MOZ Rank: 94

insulin resistance is an underappreciated feature of type 1 diabetes (T1D) (7, 13, 32, 33), resulting at least in part from the absence of endogenous insulin secretion, frequent periods of sustained hyperglycemia (12, 21, 31), and impaired sensitivity of lipolysis to inhibition by insulin, resulting in elevated free fatty acids (FFA) (24, 33).Islet transplantation restores endogenous insulin

CiteSeerX — GLUCOSE STIMULATED INSULIN RELEASE

Citeseerx.ist.psu.edu   DA: 21 PA: 16 MOZ Rank: 78

  • CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): To be a model for site-specific SOPs that define the method for quantitative determination of insulin released after glucose stimulation by the Purified Human Pancreatic Islets product manufactured for use in the CIT trials
  • RESPONSIBILITY: It is the responsibility of the Islet Cell Processing Principal Investigator

The CIT Terminology Criteria For Adverse Events V5.0 Is …

Core.ac.uk   DA: 10 PA: 17 MOZ Rank: 69

  • a descriptive terminology which can be utilized for Adverse Event (AE) reporting
  • A grading (severity) scale is provided for each AE term

Deterioration Of Glycemic Control After Corticosteroid

Deepdyve.com   DA: 16 PA: 50 MOZ Rank: 7

  • Islet autotransplantation (IAT) is performed at the time of total pancreatectomy (TP) to prevent or minimize post-surgical diabetes
  • Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass
  • We present four IAT recipients treated with oral or injected corticosteroids after transplant for

(PDF) Extending Indications For Islet …

Academia.edu   DA: 16 PA: 50 MOZ Rank: 6

Total Pancreatectomy and Islet Auto-Transplantation as Treatment for Ampullary Adenocarcinoma in the Setting of Pancreatic Ductal Disruption Secondary to Acute Necrotizing Pancreatitis.

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