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Address: 5005 Mitchelldale, Suite ,
Region: TX
City: Houston
Postal Code: 77092
Latitude: 29.830099105835
Longitude: -95.473899841309
Area Code: 713
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MTRR A66G Mutation Basics

The MTRR A66G mutation is a defect of the methionine synthase reductase gene. A mutation of the MTRR A66G gene results in poor methylation of vitamin B12. Serum B12 levels may be normal in MTRR A66G (+/+) or (+/-) individuals; however, the under-methylation of vitamin B12 may result in elevated homocysteine levels.

MTRR gene - mutations and nutrition information - Gene Food

5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) is an enzyme which interacts with methionine synthase, to ensure the continued production of the essential amino acid methionine, and is encoded for by the MTRR gene 1.. Methionine is an essential amino acid and is required for numerous processes throughout the body.

MTRR and Vitamin B12 Impact Your Homocysteine – Suzy Cohen

So MTRR turns on the first enzyme, which then turns on the second enzyme, when then converts homocysteine into something user friendly in the body, i.e. methionine. This MTRR gene activity and enzyme sequences turns on and off as the body needs but stalls out when vitamin B12 is depleted.

MTRR gene - Genetics Home Reference - NIH

The MTRR gene provides instructions for making an enzyme called methionine synthase reductase. This enzyme is required for the proper function of another enzyme called methionine synthase. Methionine synthase helps process amino acids, which are the building blocks of proteins. Specifically, it

MTR / MTRR – Homocysteine, methionine, and B12

MTR / MTRR – Homocysteine, methionine, and B12 Published by Debbie Moon on July 7, 2015. MTR (methionine synthase) and MTRR (methionine synthase reductase) are two genes involved in the conversion of homocysteine to methionine, and a couple of fairly common gene variants cause the genes to work differently.

rs1801394 - SNPedia

rs1801394, also known as A66G or Ile22Met, is a SNP in the methionine synthase MTRR gene. This gene encodes one of the two enzymes involved in the production of methionine (the other is MTR).The protein encoded by an rs1801394 allele has a lower affinity for MTR ([PMID 12416982]) and is inconsistently associated with homocysteine level, although it is a risk factor for neural tube defects

Associations of MTHFR C677T and MTRR A66G Gene

The MTRR A66G polymorphism was not associated with MetS. However, there might exist an interactive effect of the MTHFR C677T and MTRR A66G polymorphisms on MetS. Furthermore, the MTRR 66GG genotype showed a significant association with high FBG and TG. These findings are of significance, as these are valuable for the early identification of

MTR/MTRR gene mutation symptoms, testing and treatments

MTR A2756G, MTRR A66G, MTRR H595Y, MTRR K350A, MTRR R415T, MTRR S257T, and MTRR A664A all work together to convert homocysteine to methionine. MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) provides instructions for making the enzyme methionine synthase. Methionine synthase helps convert the amino acid homocysteine to methionine.

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