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Role Of Prodomain In Importin-mediated Nuclear   DA: 23 PA: 10 MOZ Rank: 33

  • The caspase-2 prodomain also regulates caspase-2 activity via a caspase recruitment domain that mediates oligomerization of procaspase-2 molecules and their subsequent autoactivation
  • In this study we sought to map specific functional regions in the caspase-2 prodomain that regulate its nuclear transport and also its activation.

Re: What Is The Function Of A Protein's Prodomain   DA: 14 PA: 44 MOZ Rank: 59

  • Usually the prodomain mediates interaction with other proteins in a complex
  • Proteolytic cleavage then removes the prodomain, activates the caspase and triggers a cascade in which caspases activate other caspases, leading eventually to the cleavage of …

The Prodomain Of BMP4 Is Necessary And Sufficient To   DA: 12 PA: 21 MOZ Rank: 35

  • The prodomain fragment that is released during proteolytic maturation lacks any known signaling activity but aids in dimerization, folding, and secretion of the active ligand
  • Moreover, prodomain swap experiments have shown that individual BMP prodomains can greatly influence the stability of cleaved mature ligands (22, 23)

Internal Cleavages Of The Autoinhibitory Prodomain Are   DA: 20 PA: 25 MOZ Rank: 48

  • Prodomain is both an inhibitor and a substrate of MT1-MMP
  • A, determination of the k i value of the PRO
  • The CAT was preincubated for 30 min at 4 °C with increasing concentrations of the PRO
  • The residual activity of the CAT was then measured using Mca-PLGL-Dpa-AR-NH 2
  • A representative experiment is shown.

PNAS Plus: The Prodomain Of BMP4 Is Necessary And   DA: 20 PA: 25 MOZ Rank: 49

The prodomain fragment that is released during proteolytic maturation lacks any known signaling activity but aids in dimerization, folding, and secretion of the active ligand ().Moreover, prodomain swap experiments have shown that individual BMP prodomains can greatly influence the stability of cleaved mature ligands (22, 23).The prodomains of BMP7 and BMP4 play distinct roles in …

The Prodomain Of Caspase-3 Regulates Its Own Removal …   DA: 14 PA: 27 MOZ Rank: 46

  • The 28 amino acid prodomain of caspase-3 is highly conserved (Fig
  • S1A), therefore we sought to determine if there were specific regions within the prodomain that were important for …

ProDemand Automotive Repair Information   DA: 17 PA: 17 MOZ Rank: 40

ProDemand is the premier online solution for automotive repair information, vehicle maintenance, diagnostic data, and labor estimating.

A Novel Familial Mutation In The PCSK1 Gene That Alters   DA: 17 PA: 16 MOZ Rank: 40

  • The fact that the N309K mutant undergoes slowed prodomain removal implies that the identity of the oxyanion hole residue contributes to this intramolecular cleavage event
  • Interestingly, normal prodomain removal of a mouse PC1/3 N309D mutant was observed in in vitro translational experiments; in this work, potential effects of this substitution

Characterization Of METH-1/ADAMTS1 Processing …   DA: 11 PA: 34 MOZ Rank: 53

  • lacks the prodomain, indicating processing at this site (6)
  • In addition to removal of the prodomain, secondary processing can also take place and may also be important for activity
  • Recent studies on aggrecanase-1/ADAMTS4 suggest the possibility that a C-terminal fragment of this protein may function as a

Intellectual ProDomain – Protecting Editions   DA: 12 PA: 12 MOZ Rank: 33

  • Welcome to IProd ! Here we protect your self developed technology tools, software, electronic books, project ideas and more ! Our mission is to ensure that your frameworks cannot be compromised by third parties
  • In simple words, we protect your work editions ! Learn more IProd In …

TGF-β Prodomain Alignments Reveal Unexpected Cysteine   DA: 16 PA: 18 MOZ Rank: 44

  • Prodomain alignments revealed that six structural features of 17 are well conserved: three in the straitjacket and three in the arm
  • Alignments also revealed unexpected cysteine conservation in the “LTBP-Association region” upstream of the straitjacket and in β8 of the bowtie in 14 proteins from all three subfamilies

Development Of ADAM10 Prodomain As A Therapeutic Agent   DA: 12 PA: 25 MOZ Rank: 48

  • The disintegrin-metalloprotease ADAM10 is required for the activation of several critical signaling pathways (e.g
  • HER2 signaling) involved in cellular transformation and tumor progression
  • This grant proposes to develop the ADAM10 prodomain-Fc fusion protein as a novel cancer therapeutic
  • * Information listed above is at the time of submission.

Val66Met Polymorphism Of BDNF Alters Prodomain Structure   DA: 14 PA: 20 MOZ Rank: 46

  • BDNF prodomain is expressed in the hippocampus and secreted
  • The hippocampus is a key regulator of learning and memory and dysfunction of …

Free Whois Service {s}   DA: 14 PA: 19 MOZ Rank: 46

SEO - Alexa Traffic Ranks (Average of last 30 days) SEO Global Rank: SEO Reach Rank: Country: SEO Rank in Country: Last Update: Global Rank Trend of The Past Year

Protein Precursor   DA: 16 PA: 23 MOZ Rank: 53

  • A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule
  • The name of the precursor for a protein is often prefixed by pro-.Examples include proinsulin and proopiomelanocortin, which are both prohormones.

Anti-Caspase 12 Antibody, Prodomain, Aa 100-116 Chemicon   DA: 20 PA: 24 MOZ Rank: 59

  • Detect Caspase 12 using this Anti-Caspase 12 Antibody, prodomain, aa 100-116 validated for use in WB, IH
  • Caspase-12 is a stress induced caspase localized to the ER and activated upon ER stress.

Prodomain Processing Of Asp1 (BACE2) Is Autocatalytic   DA: 21 PA: 38 MOZ Rank: 75

  • Prodomain Processing of Asp1 (BACE2) Is Autocatalytic
  • Generation of the amyloid peptide through proteolytic processing of the amyloid precursor protein by β- and γ-secretases is central to the etiology of Alzheimer's disease
  • The highly elusive β-secretase was recently identified as a transmembrane aspartic proteinase, Asp2 (BACE).

MMP-14, Human, Prodomain, Catalytic Domain, And Hemopexin   DA: 20 PA: 24 MOZ Rank: 61

The following domains and sequence regions are distinguished in MT1-MMP: Prodomain (Ser1-Arg88), catalytic domain (Tyr89-Gly261), junction between catalytic domain and hemopexin domain (Gly262-Gly292), hemopexin-like domain (Pro293-Cys485) and C-terminal sequence (Pro486-Val559) with transmembrane segment.


  • Project Methods We hypothesize that the prodomain-enhanced muscularity results from its depressing effects on myostatin activity, and direct intramuscular injection of prodomain DNA is an effective means of promoting animal muscle growth
  • This project initially investigates molecular interactions between myostatin and its prodomain, and metabolic interactions between muscle …

TGF-b Prodomain Alignments Reveal Unexpected Cysteine   DA: 16 PA: 36 MOZ Rank: 71

  • The prodomain sequences responsible for full-length vs
  • cys-tine knot tree discrepancies have not been identified
  • While the prodomain has long been known to be required for proper folding and dimerization of the ligand (Gentry and Nash 1990; Gray and Mason 1990), formal definition of cleavage sites came later (Degnin et al

Recombinant Human BDNF ProDomain Protein Alomone Labs   DA: 15 PA: 29 MOZ Rank: 64

  • Recombinant human BDNF proDomain protein (#B-245) is a highly pure, recombinant, and biologically active protein
  • Certificate of Analysis SDS New Generate a Quote
  • For research purposes only, not for human use
  • For research purposes only, not for human use.

Asparagine Endopeptidase   DA: 16 PA: 30 MOZ Rank: 67

  • Legmains are produced as inactive precursor zymogens
  • their C-terminal domain binds over their active site (where a substrate would normally bind), inhibiting activity
  • Once in the acidic environment of the vacuole or lysosome, the prodomain is cleaved off to reveal the active enzyme.

Highly Specific Detection Of Myostatin Prodomain By An   DA: 17 PA: 16 MOZ Rank: 55

  • Myostatin prodomain was detectable in 143 (84.6%) of these 169 heart failure patients
  • Interestingly, the median myostatin prodomain concentration was 2.6ng/ml (25th-75th percentiles 1-6ng/ml) and was significantly lower compared to the older healthy group (p<0.001, see Figure 4).

Recombinant Human BDNF ProDomain (Val66Met) Protein   DA: 15 PA: 32 MOZ Rank: 70

  • Recombinant human BDNF proDomain (Val66Met) protein (#B-445) is a highly pure, recombinant, and biologically active protein
  • Alternative Name Brain-Derived Neurotrophic Factor proDomain (Val66Met) MW: 12.4 kDa

Binding Of Caspase-3 Prodomain To Heat Shock Protein 27   DA: 11 PA: 39 MOZ Rank: 74

  • The activation of caspase-3 requires its processing from an inactive precursor
  • Here we show that the small heat shock protein 27 (Hsp27) associates with caspase-3 and protein-protein interaction experiments in vivo and with purified proteins demonstrate a direct interaction between Hsp27 and the amino-terminal prodomain of caspase-3.

Variant Brain-derived Neurotrophic Factor (BDNF) (Met66   DA: 23 PA: 10 MOZ Rank: 58

  • Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and cardiovascular development and function
  • Recently, a common single nucleotide polymorphism in the bdnf gene, resulting in a valine to methionine substitution in the prodomain (BDNF(Met)), has been shown to lead to memory impairment and susceptibility to neuropsychiatric disorders in humans heterozygous for the

Role Of The Prodomain In Folding And Secretion Of Rat   DA: 12 PA: 22 MOZ Rank: 60

  • Role of the Prodomain in Folding and Secretion of Rat Pancreatic Carboxypeptidase A1
  • Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235-9041, and Hormone Research Institute, University of California

Growth Factors And Hormones Pro‐peptides: The Unexpected   DA: 23 PA: 27 MOZ Rank: 77

  • The prodomain‐dependent folding in ‘trans’ suggests that the prodomains’ chaperone activity is conserved in the neurotrophin family
  • (2) Prodomains might interact with chaperones to direct their intracellular trafficking to their final subcellular destination
  • A very well documented example of this process is the interaction of the BDNF

Regulation Of The α‐secretase ADAM10 By Its Prodomain And   DA: 29 PA: 26 MOZ Rank: 83

  • Expression of the prodomain of ADAM10 in trans together with wild-type ADAM10 led to a significant decrease of APPsα release, indicating an inhibitory function of the prodomain with regard to the proteolytic activity of ADAM10 (Fig
  • The overexpressed ADAM10 prodomain also impaired the release of APPsα by endogenous ADAM 10.

The Xenopus Lefty (xlefty) Prodomain Negatively Regulates   DA: 24 PA: 20 MOZ Rank: 73

  • Lefty prodomain has been shown to be a prerequisite for normal functionality (Sakuma et al., 2002; Westmoreland et al., 2007)
  • When an Xlefty cleavage mutant is made by mutating the two potential cleavage sites into non-cleavable sites, this mutated Xlefty derivative is unable to block Nodal in a frog animal cap assay (Sakuma et al., 2002;

The Prodomain Of Ssy5 Protease Controls Receptor-Activated   DA: 16 PA: 25 MOZ Rank: 71

  • Extracellular amino acids induce the yeast SPS sensor to endoproteolytically cleave transcription factors Stp1 and Stp2 in a process termed receptor-activated proteolysis (RAP)
  • Ssy5, the activating endoprotease, is synthesized with a large N-terminal prodomain and a C-terminal chymotrypsin-like catalytic (Cat) domain
  • During biogenesis, Ssy5 cleaves itself and the prodomain

Prodomain–growth Factor Swapping In The Structure Of Pro   DA: 16 PA: 40 MOZ Rank: 87

  • Prodomain–growth factor swapping in the structure of pro-TGF-β1 The Harvard community has made this article openly available
  • Please share how this access benefits you
  • Your story matters Citation Zhao, Bo, Shutong Xu, Xianchi Dong, Chafen Lu, and Timothy A
  • Prodomain–growth factor swapping in the structure of pro-TGF

#1 Industrial Paint Suppliers & Distributors In The UK   DA: 17 PA: 17 MOZ Rank: 66

Promain Paints: The UK’s largest commercial / industrial paint and surface coatings company with over 35 years experience in industrial paint supplies.

Frontiers Renal ADAM10 And 17: Their Physiological And   DA: 19 PA: 39 MOZ Rank: 91

  • The recombinant mouse ADAM10 prodomain is a potent competitive inhibitor of human ADAM10 activity with higher selectively (Moss et al., 2007)
  • ADAM17 prodomains could also be valuable inhibitors
  • A stable form of the auto-inhibitory TPD (TACE prodomain) inhibits ADAM17, but does not prevent the related ADAM10 activity (Wong et al

Structural Basis For The Effective Myostatin Inhibition Of   DA: 12 PA: 35 MOZ Rank: 81

  • Myostatin inhibition is one of the promising strategies for treating muscle atrophic disorders, including muscular dystrophy
  • It is well-known that the myostatin prodomain derived from the myostatin precursor acts as an inhibitor of mature myostatin
  • In our previous study, myostatin inhibitory minimum peptide 1 (WRQNTRYSRIEAIKIQILSKLRL-amide) was discovered from the mouse myostatin prodomain

Comparing Sequence And Structure Of Falcipains And Human   DA: 32 PA: 35 MOZ Rank: 15

  • Prodomain-catalytic domain interaction studies and short inhibitor peptide design
  • To determine the prodomain inhibitory mechanism, residue interactions between prodomain and catalytic domain of plasmodial and human partial zymogen complexes were evaluated using the Protein Interaction Calculator (PIC) web server .

(PDF) Inhibitory Potential Of Prodomain Of Plasmodium   DA: 16 PA: 50 MOZ Rank: 14

  • Inhibitory Potential of Prodomain of Plasmodium falciparum Protease Serine Repeat Antigen 5 for Asexual Blood Stages of Parasite Asrar Alam, Virander S
  • Chauhan* Malaria Research Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India Abstract Plasmodium falciparum serine repeat antigen 5 (SERA5) is a target for both drug and vaccine intervention against …

The Prodomain Of BMP4 Is Necessary And Sufficient To   DA: 12 PA: 35 MOZ Rank: 84

  • The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo Judith M
  • Neugebauera,1, Sunjong Kwonb,1,2, Hyung-Seok Kima, Nathan Donley b, Anup Tilak , Shailaja Soporyb,3, and Jan L
  • Christiana,c,4 Departments of aNeurobiology and Anatomy and cInternal Medicine, Division of Hematology and Hematologic Malignancies, University of …

Meprin β Induces Activities Of A Disintegrin And   DA: 29 PA: 31 MOZ Rank: 98

  • and 17by specific prodomain cleavage.FASEB J
  • KEY WORDS: proteolysis † zymogen activation † inflammation † ADAM Meprin b is a zinc-dependent metalloprotease belonging

The BDNF Val66Met Prodomain Disassembles Dendritic Spines   DA: 12 PA: 37 MOZ Rank: 88

  • added recombinant Val or Met prodomain (10 ng/mL) to DIV21 cultured hippocampal cells and analyzed their morphology
  • By 40 min of the Met prodomain treatment, there was a progressive transitioning from the mature mushroom spines into thin/filopo-dia-like protrusions, resulting in nearly 60% decrease in mush-room spines (Figures 1A and 1B).

Zinc Induced Structural Changes In The Intrinsically   DA: 12 PA: 45 MOZ Rank: 97

  • Human brain derived neurotrophic factor (BDNF) encodes a protein product consisting of a C-terminal mature domain (mature BDNF) and an N-terminal prodomain, which is an intrinsically disordered protein
  • A common single nucleotide polymorphism in humans results in a …

(PDF) The Prodomain Of BMP4 Is Necessary And Sufficient To   DA: 16 PA: 50 MOZ Rank: 9

  • The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo
  • Regulation of Bone Morphogenetic Protein-4 Activity by Sequence Elements within the Prodomain

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