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Scriptaid ≥99%(HPLC) Selleck HDAC Inhibitor   DA: 19 PA: 24 MOZ Rank: 43

  • Scriptaid (GCK 1026) is an inhibitor of HDAC
  • It shows a greater effect on acetylated H4 than H3
  • Scriptaid (6 μM) results in a >100-fold increase in histone acetylation in PANC-1 cell
  • Scriptaid (8 μM) is not lethal to PANC-1 cell and has limited effects (80% survival) on MDAMB-468.

Scriptaid C18H18N2O4   DA: 24 PA: 19 MOZ Rank: 44

  • Scriptaid | C18H18N2O4 - PubChem
  • National Center for Biotechnology Information
  • 8600 Rockville Pike, Bethesda, MD, 20894 USA
  • Department of Health and Human Services.

Scriptaid ≥95%, Solid 287383-59-9   DA: 20 PA: 26 MOZ Rank: 48

  • Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones
  • It improves transcriptional activity and protein expression
  • Scriptaid inhibits tumor growth
  • It decreases telomerase activity and stimulates glioma cell apoptosis.

A Novel Histone Deacetylase Inhibitor, Scriptaid, Enhances   DA: 23 PA: 10 MOZ Rank: 36

  • Scriptaid treatment of three ER negative cell lines, MDA-MB-231, MDA-MB-435 and Hs578t, resulted in significant growth inhibition and increased acetylation of H3 and H4 histone tails
  • Quantitative Real Time PCR showed 2000-20,000-fold increase of ER mRNA transcript in all three cell lines after 48 h of Scriptaid treatment.

Scriptaid (CAS 287383-59-9)   DA: 18 PA: 24 MOZ Rank: 46

  • Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems
  • 1 It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo
  • 2,3 Scriptaid also facilitates the cloning of inbred mouse strains produced by

The Histone Deacetylase Inhibitor Scriptaid Enhances   DA: 23 PA: 10 MOZ Rank: 38

  • The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice Reproduction

Drugs Targeting Epigenetic Histone Acetylation In Vascular   DA: 19 PA: 35 MOZ Rank: 60

  • HDAC inhibitor, Scriptaid, to elegantly demonstrate its pro-tective effects in vitro and in vivo in a mouse model of neointimal thickening
  • They demonstrate that mitogens in-duce the transcriptional upregulation of HDACs 1 to 3 in rat VSMCs
  • Knockdown of these 3 HDACs with short interfer-ing RNAs or pharmacological inhibition of HDAC could

RARβ Acts As Both An Upstream Regulator And Downstream   DA: 29 PA: 30 MOZ Rank: 66

  • inhibitor, such as trichostatin A or scriptaid (22, 24, 25)
  • One mechanism by which HDAC inhibitors can enhance retinoid-induced apoptosis is through induction and nu-clearexportofRAreceptorb (RARb) and orphan nuclear receptor, nerve growth factor (NUR77) (24)
  • NUR77 is overexpressed in multiple cancer types, including colon,

Cassandra Fleming   DA: 15 PA: 30 MOZ Rank: 53

  • European Journal of Medicinal Chemistry January 15, 2019
  • Fluorescent scriptaid analogues with excellent HDAC6 selectivity (HDAC1/6 > 500) and potency (HDAC6 IC50 < 5 nM) have been synthesised and evaluated
  • The highly fluorescent nature of the compounds (up to ΦF = 0.83 in DMSO and 0.38 in aqueous buffer) makes them ideally suited for

Scriptaid, HDAC Inhibitor (CAS 287383-59-9) (ab120883) Abcam   DA: 13 PA: 39 MOZ Rank: 61

  • Functional Studies - Scriptaid, HDAC inhibitor (ab120883) ab10812 staining histone H3 (acetyl K9) in A549 cells treated with scriptaid (ab120883), by ICC/IF
  • Increase in histone H3 (acetyl K9) expression correlates with increased concentration of scriptaid, as described in literature
  • The cells were incubated at 37°C for 24 hour in media

Scriptaid (Scriptide) HDAC Inhibitor MedChemExpress   DA: 22 PA: 15 MOZ Rank: 47

  • Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research
  • Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus (EBV)-associated lymphomas treatment
  • Scriptaid (1 µg/mL) treatment inhibits cell growth in breast cancer cell lines, results in increased accumulation of both acetyl H3 and

Scriptaid (CAS 287383-59-9): R&D Systems   DA: 18 PA: 24 MOZ Rank: 53

  • TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h
  • Cell lysates were analysed by western blot
  • Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry

Scriptaid Supplier CAS 287383-59-9 Tocris Bioscience   DA: 14 PA: 24 MOZ Rank: 50

  • Citations are publications that use Tocris products
  • Selected citations for Scriptaid include: Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition.

Scriptwriting Made Easy!   DA: 17 PA: 17 MOZ Rank: 47

Script Aid’s a unique community membership site for everything Scriptwriting in one place! Enjoy selected, high-quality content for all of your Scriptwriting needs and connect with other Scripters in Script Aid’s advanced forum! But mostly feel supported and have fun!

Effect Of Scriptaid, A Histone Deacetylase Inhibitor, On   DA: 21 PA: 38 MOZ Rank: 73

  • Scriptaid treatment was given for 10 h immediately after reconstruction of HMC and PA embryos
  • Treatment of HMC embryos with 500 or 1000 nmol/L scriptaid significantly increased (P < 0.01) the cleavage rate (91.3 ± 2.8 and 91.9 ± 2.0%, respectively) than that of controls (80.7 ± 2.4%).

HDAC Inhibitor, Scriptaid, Induces Glioma Cell Apoptosis   DA: 23 PA: 37 MOZ Rank: 75

  • Scriptaid‐mediated suppression of telomerase activity in glioma cells is JNK independent
  • Telomerase is composed primarily of the catalytic subunit (hTERT) and the RNA template (hTERC), and hallmarks of telomere dysfunction include chromosome end fusion and telomere shortening, which can lead to cell‐cycle arrest

The Histone Deacetylase Inhibitor Scriptaid Improves In   DA: 21 PA: 38 MOZ Rank: 75

  • Scriptaid is a novel HDAC inhibitor with low toxicity
  • Recently, it was reported that Scriptaid has a beneficial effect on the efficiency of sheep cloning
  • The current study confirmed this benefit and further defined an optimal concentration and duration of Scriptaid treatment for improving development of cloned ovine embryos.

Scriptaid ≥99%(HPLC) HDAC Inhibitor AdooQ®   DA: 13 PA: 15 MOZ Rank: 45

  • Scriptaid is an HDAC inhibitor (histone deacetylase)
  • Products are for laboratory research use only

Scriptaid C18H18N2O4 ChemSpider   DA: 18 PA: 29 MOZ Rank: 65

  • Scriptaid(Scriptide; GCK-1026) is an inhibitor of HDAC; shows a greater effect on acetylated H4 than H3
  • MedChem Express IC50 Value:; Target: HDAC; in vitro: Scriptaid induces high rates of somatic cell nuclear transfer (SCNT) oocytes development to the blastocyst stage and allowed full-term development (3.4, 4.2, 7.6, 6.8, and 4.1%) with all

Anticancer Effect Of Histone Deacetylase Inhibitor   DA: 20 PA: 25 MOZ Rank: 64

  • Scriptaid treatment triggered HCC cell apoptosis via transcriptional activation of p21
  • Importantly, we found that scriptaid treatment evidently reduced the weights and volumes of HCC cell-line HepG2 primary tumors
  • These data provide an insight into the therapeutic intervention of advanced HCC.

Scriptaid CAS#287383-59-9 HDAC Inhibitor MedKoo   DA: 14 PA: 15 MOZ Rank: 49

  • Scriptaid, also known as GCK 1026, is a HDAC inhibitor
  • Scriptaid protects against traumatic brain injury via modulation of PTEN and AKT pathway
  • Scriptaid improves in vitro development and nuclear reprogramming of somatic cell nuclear transfer bovine embryos
  • Scriptaid enhances the response of human tumor cells to radiation
  • Scriptaid, induces glioma cell apoptosis …

The HDAC Inhibitors Scriptaid And LBH589 Combined With The   DA: 17 PA: 16 MOZ Rank: 54

  • Scriptaid and LBH589 both enhanced the oncolytic activity of Delta24-RGD in 5/8 and 4/8 of the tested GSCs with enhancement factors ranging from 1.2–2.9 for Scriptaid and 1.2–4.4 for LBH589, respectively
  • SAHA and VPA were less effective than MS275, LBH589 and Scriptaid in enhancing viral oncolysis.

Scriptaid CAS:287383-59-9 HDAC Inhibitor,novel And   DA: 16 PA: 23 MOZ Rank: 61

  • Scriptaid, identified by a high-throughput transcriptional screening, is a novel histone deacetylase (HDAC) with specific potency towards class I HDACs (50% inhibition concentration IC 50 values of 0.6 μM for HDAC1 and HDAC3 and 1 μM for HDAC8)
  • Scriptaid shares a similar chemical structure with several others hydroxamic acid-containing HDAC inhibitors (such as TSA and …

HDAC Inhibitor, Scriptaid, Induces Glioma Cell Apoptosis   DA: 23 PA: 41 MOZ Rank: 87

  • Scriptaid reduced glioma cell viability by increasing Jun N-terminal kinase (JNK) activation
  • Although script aid induced activation of both p38MAPK and JNK, it was the inhibition of JNK that attenuated scriptaid-induced apoptosis significantly.

Effects Of Scriptaid On The Histone Acetylation, DNA   DA: 18 PA: 27 MOZ Rank: 69

When 96 blastocysts developed from Scriptaid-treated SCNT embryos were transferred into 48 recipients, 11 recipients (22.9%) became pregnant, whereas only one recipient (11.1%) became pregnant following transfer of 18 blastocysts developed from untreated SCNT embryos into nine recipients.

Scriptaid/exercise-induced Lysine Acetylation Is Another   DA: 23 PA: 36 MOZ Rank: 84

  • Titin serves important functions in skeletal muscle during exercise, and posttranslational modifications of titin participate in the regulation of titin-based sarcomeric functions
  • Scriptaid has exercise-like effects through the inhibition of HDAC and regulatory acetylation of proteins
  • However, it remains mostly unclear if exercise could result in titin’s acetylation and whether Scriptaid


  • Scriptaid was the most potent hydroxamic acid inhibitor (IC 50 = 39 nM)
  • In comparison, the carboxylate histone deacetylase inhibitors sodium valproate, sodium butyrate, and 4-phenylbutyrate were less potent (IC 50 range 1–5 mM).

Scriptaid/exercise-induced Lysine Acetylation Is Another   DA: 23 PA: 40 MOZ Rank: 90

  • Scriptaid disrupted the class IIa HDAC corepressor complex and increased histone 3 lysine 9 acetylation (H3K9ac) and MEF2 (myocyte enhancer factor 2) transcription activity
  • Moreover, Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice (14)
  • In another study, Scriptaid was shown to affect histone acetylation and

PLOS ONE: The HDAC Inhibitors Scriptaid And LBH589   DA: 17 PA: 16 MOZ Rank: 61

  • Results Scriptaid and LBH589 acted synergistically with Delta24-RGD in approximately 50% of the GSCs
  • Both drugs moderately increased αvβ3 integrin levels and viral infection in responding but not in non-responding GSCs
  • LBH589 moderately increased late viral gene expression, however, virus titration revealed diminished viral progeny

Scriptaid CAS 287383-59-9 SCBT   DA: 12 PA: 25 MOZ Rank: 66

  • Scriptaid is an HDAC inhibitor (histone deacetylase)
  • HDACs are modifying enzymes that are involved in the regulation of gene transcription, cell proliferation, and chromosome remodeling
  • Scriptaid has been reported to inhibit all three class I HDACs (HDAC1, HDAC3, HDAC8).

Scriptaid Corrects Gene Expression Of A Few Aberrantly   DA: 18 PA: 27 MOZ Rank: 75

  • Scriptaid treatment resulted high expression of COX5A and very low expression of GPD1L, EIF3E, and GSTA3
  • Scriptaid also reduced the number of 5-Methylcytidine-positive nuclei in blastocyst stage embryos (p < 0.0003)
  • Scriptaid treatment significantly affected gene expression in 7 of the 14 transcripts evaluated and returned 3 genes to BLIVV

Scriptaid Inhibits Cell Survival, Cell Cycle, And Promotes   DA: 14 PA: 34 MOZ Rank: 79

  • Scriptaid treatment for 24 hours compared with the control group (Fig
  • Subsequently, we also detected the signif-icant increase in endogenous mRNAlevels of Bad, p21, and PTEN with Scriptaid treatment in U266 and IM9 cell lines (Fig
  • p53 can enhance cancer cell apoptosis due to DNA damage [19,20]

Single-cell Assessment Of Transcriptome Alterations   DA: 14 PA: 28 MOZ Rank: 74

  • Scriptaid increases LTC-IC during short-term ex vivo culture
  • After ovenight recovery in the same 3 cytokines, cryopreserved CD133+ UCB HSPCs were cultured on nanofibre scaffolds with 3 cytokines

Effect Of Treatment With Scriptaid On Development Of   DA: 16 PA: 42 MOZ Rank: 91

  • Scriptaid also belongs to the class of hydroxamic acid-containing histone-deacetylase inhibitors including trichostatin A
  • The objective of this study was to investigate the effect of scriptaid treatment on in vitro developmental ability of bovine NT embryos
  • As donor cells for NT, ear skin fibroblast cells of passages 2 to 4 were used

Effects Of The Histone Deacetylase Inhibitor ‘Scriptaid   DA: 16 PA: 31 MOZ Rank: 81

  • Following Scriptaid treatment, the percentage of high-quality (Grade A) blastocysts was increased in ROSI-S group
  • Our results demonstrated that embryos derived by ROSI following treatment with Scriptaid had a higher proportion of Oct4-positive blastomeres
  • Effect of Scriptaid on the methylation states of imprinted genes

Anti-Cancer Effects Of Epigenetics Drugs Scriptaid And   DA: 20 PA: 15 MOZ Rank: 70

Title:Anti-Cancer Effects of Epigenetics Drugs Scriptaid and Zebularine in Human Breast Adenocarcinoma Cells VOLUME: 21 Author(s):Zhi Hung Yap, Wei Yang Kong, Abdur Rahmaan Azeez, Chee-Mun Fang and Siew Ching Ngai* Affiliation:School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor, …

The Histone Deacetylase Inhibitor Scriptaid Enhances   DA: 21 PA: 17 MOZ Rank: 74

  • Scriptaid concentration on the full-term development, we decided to use 250 nM of Scriptaid for all subsequent experiments
  • Next, we applied Scriptaid to SCNT oocytes produced using cumulus cells of a wide range of donor mouse strains
  • These included hybrid BD129F1 (BDF1 × 129/Sv), and inbred C57BL/6, C3H/He, DBA/2, and 129/Sv mouse strains.

Epigenetics Of ER-Negative Primary Breast Cancer   DA: 16 PA: 21 MOZ Rank: 74

Epigenetics has emerged as a promising field for the assessment of hormone receptor status in breast cancer, and offers an opportunity for development of novel therapies targeting epigenetic

Inhibition Of RNA Synthesis During Scriptaid Exposure   DA: 22 PA: 40 MOZ Rank: 100

Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos in Reproduction Authors: Vitor Braga Rissi 1 , Werner Giehl Glanzner 2 , Mariana Priotto de Macedo 2 , Lady Katerine Serrano Mujica 1 , Karine Campagnolo 1 , Karina Gutierrez 2 , Alessandra Bridi 1 , Hernan Baldassarre 2 , Paulo Bayard Dias

Fetal Hemoglobin Induction By The Histone Deacetylase   DA: 25 PA: 50 MOZ Rank: 11

  • Scriptaid induced gamma-globin in K562 cells and human erythroid progenitors
  • Furthermore the p38-selective inhibitor SB203580 completely reversed the ability of scriptaid to induce HbF
  • To test the potential efficacy of scriptaid in humans, in vivo studies were completed in beta-YAC transgenic mice where the gamma-gene is completely silenced.

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