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Experimental Ebola Drug ZMapp Begins Clinical Trials In Liberia

Medicalxpress.com   DA: 17 PA: 50 MOZ Rank: 67

A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection | NEJM

A Randomized, Controlled Trial Of ZMapp For Ebola Virus

Nejm.org   DA: 12 PA: 31 MOZ Rank: 44

In this trial conducted primarily in West Africa during an outbreak, ZMapp (a cocktail of three monoclonal Ebola virus causes a devastating clinical illness that is associated with high

Safety And Pharmacokinetics Of A Single ZMappTM

Clinicaltrials.gov   DA: 22 PA: 21 MOZ Rank: 45

9 rows · This is a Phase 1a, open-label study to assess the safety and pharmacokinetics of a single

Study Finds Ebola Treatment ZMapp Holds Promise, Although

Nih.gov   DA: 11 PA: 50 MOZ Rank: 64

  • Study finds Ebola treatment ZMapp holds promise, although results not definitive. Trial shows rigorous clinical research feasible during a public health emergency
  • A clinical trial to evaluate the experimental Ebola treatment ZMapp found it to be safe and well-tolerated; however, because of the waning Ebola epidemic, the study enrolled too few people to determine definitively whether it is a …

Investigational Therapeutics For The Treatment Of People

Clinicaltrials.gov   DA: 18 PA: 21 MOZ Rank: 43

The triple monoclonal antibody product ZMapp was studied through a randomized controlled trial (RCT) in the 2014-2016 West African outbreak and remains perhaps the best characterized of the available investigational products, but the end of that outbreak forced the RCT to close prior to crossing pre-specified evidentiary boundaries.

A Randomized, Controlled Trial Of Ebola Virus Disease

Nejm.org   DA: 12 PA: 31 MOZ Rank: 48

ZMapp was chosen as the control on the basis of data from the Partnership for Research on Ebola Virus in Liberia II (PREVAIL II) trial. 11 The current trial was originally designed in November

Clinical Trial Of Investigational Ebola Treatments Begins

Niaid.nih.gov   DA: 17 PA: 50 MOZ Rank: 73

  • Results from that study conducted in the United States and West Africa during the 2014-16 Ebola outbreak, indicated that ZMapp appeared to be beneficial, but the clinical trial ultimately did not enroll enough participants to definitively establish the drug’s efficacy because the Ebola outbreak at that time ended
  • Despite the lack of definitive evidence of efficacy, the investigators believe ZMapp is …

Two Drugs Reduce Risk Of Death From Ebola National

Nih.gov   DA: 11 PA: 50 MOZ Rank: 68

  • The trial, called Pamoja Tulinde Maisha (PALM), was funded in part by NIAID
  • Results were published on November 27, 2019, in the New England Journal of Medicine
  • After results from the first 499 participants had been reviewed, the trial’s safety monitors recommended that two drugs—ZMapp and remdesivir—be dropped from the remainder of the trial.

WHO Group Outlines New Approach To Clinical Trials During

Biostat.washington.edu   DA: 26 PA: 50 MOZ Rank: 84

  • From 2014 to2016, a clinical trial in West Africa with an optimized standard-of-care control arm evaluated a cocktail of monoclonal antibodies called ZMapp as a potential treatment for Ebola
  • But the outbreak waned and the trial was terminated without reaching its …

Trial Offers Mixed View Of Ebola Drug ZMapp CIDRAP

Cidrap.umn.edu   DA: 18 PA: 50 MOZ Rank: 77

  • ZMapp treatment began within 12 to 24 hours of trial enrollment, and clinical status was recorded daily for 4 weeks, with a final check on day 58
  • "We were not able to enroll the desired number of patients," said Davey, who said that 100 patients in both the treatment and control arms of the study would have conferred greater power.

Trial Of Ebola Drug ZMapp Launches In Liberia, US CIDRAP

Cidrap.umn.edu   DA: 18 PA: 50 MOZ Rank: 78

The National Institutes of Allergy and Infectious Diseases (NIAID) announced today that it and Liberia's government have launched the first clinical trial of ZMapp, a monoclonal antibody treatment that has been used on an emergency basis to treat some Ebola patients, especially sick health workers who were evacuated from the outbreak region.

Game-changing Clinical Trials For Ebola Treatment In Congo

Rfi.fr   DA: 10 PA: 50 MOZ Rank: 71

  • The drugs selected to be part of the clinical trials are ZMapp, mAb 114, Remdesivir and REGN-EB3
  • Patients must consent to their inclusion in the trials and the treatments will be selected at …

Two Ebola Treatments Prove Highly Effective In A Clinical

Sciencenewsforstudents.org   DA: 30 PA: 50 MOZ Rank: 92

  • The drug trial began in November
  • Participants were randomly given one of four experimental treatments
  • Three were antibody treatments: mAb114, REGN-EB3 and ZMapp
  • (Antibodies are proteins that the immune system harnesses to help fight germs and other “foreign” materials.) The other treatment was an antiviral drug, remdesivir.

For The First Time, Clinical Trial Data Show Ebola Drugs

Statnews.com   DA: 16 PA: 50 MOZ Rank: 79

In the current clinical trial, called the PALM study — the acronym stands for Pamoja Tulinde Maisha, which is Swahili for Together Save Lives …

Hopes Of Ebola Drug Breakthrough In ZMapp Trials Ebola

Theguardian.com   DA: 19 PA: 50 MOZ Rank: 83

The Belgian scientist who discovered Ebola in 1976 said it was vital to start clinical trials of ZMapp.

Experimental Ebola Drug ZMapp Begins Clinical Trials In

Medicalxpress.com   DA: 17 PA: 50 MOZ Rank: 82

  • Experimental Ebola drug ZMapp begins clinical trials in Liberia
  • ZMapp, the experimental Ebola drug that won notoriety when it was given to a …

A Randomized, Controlled Trial Of Ebola Virus Disease

Pubmed.ncbi.nlm.nih.gov   DA: 23 PA: 23 MOZ Rank: 62

  • Both MAb114 and REGN-EB3 were superior to ZMapp in reducing mortality from EVD
  • Scientifically and ethically sound clinical research can be conducted during disease outbreaks and can help inform the outbreak response

ZMapp FDA Approval Status

Drugs.com   DA: 13 PA: 19 MOZ Rank: 49

  • ZMapp is a new drug in development for the treatment of ebola virus disease
  • ZMapp information includes news, clinical trial results and side effects.

ZMapp Trial Shows Signs Of Efficacy, But Data Insufficient

Globalbiodefense.com   DA: 20 PA: 50 MOZ Rank: 88

The small clinical trial, known as PREVAIL II, showed that the ZMapp monoclonal antibody cocktail was well-tolerated and showed promise; however, due to decreasing incidence in Ebola, the study could not enroll enough volunteers to determine definitively whether it is a better treatment for EVD than supportive care only.

National Institute Of Allergy And Infectious Diseases (NIAID)

Niaid.nih.gov   DA: 17 PA: 50 MOZ Rank: 86

  • Trial Shows Rigorous Clinical Research Feasible During a Public Health Emergency
  • A clinical trial to evaluate the experimental Ebola treatment ZMapp found it to be safe and well-tolerated; …

Experimental Ebola Drug ZMapp Begins Clinical Trials In

Latimes.com   DA: 15 PA: 50 MOZ Rank: 85

ZMapp, the experimental Ebola drug that won notoriety when it was given to a handful of infected aid workers at the height of the epidemic, will now begin clinical testing in Liberian treatment

ZMapp® FAQ

Mappbio.com   DA: 11 PA: 11 MOZ Rank: 43

  • ZMapp® is an experimental therapy that must be tested in clinical trials for safety (and efficacy)
  • Other monoclonal antibody therapies, of which there are over 30 approved by the FDA, have a good safety record.

Clinical Trial On Ebola Virus: ZMapp, Remdesivir, MAb114

Ichgcp.net   DA: 10 PA: 37 MOZ Rank: 69

  • ICH GCP The triple monoclonal antibody product ZMapp was studied through a randomized controlled trial (RCT) in the 2014-2016 West African outbreak and remains perhaps the best characterized of the available investigational products, but the end of that outbreak forced the RCT to close prior to crossing

WHO Table Of Drug Clinical Trials

Who.int   DA: 11 PA: 50 MOZ Rank: 84

  • A clinical trial started in early March 2015 in Port Loko, Sierra Leone, led by Oxford University with funding from the Wellcome Trust
  • The trial was halted on 19 June on the grounds of having met one of the clinical endpoints
  • Continuing enrolment was not likely to demonstrate an overall therapeutic benefit

Nubia's Mother: Being Pregnant In The Time Of Experimental

Pubmed.ncbi.nlm.nih.gov   DA: 23 PA: 10 MOZ Rank: 57

  • The infant received ZMapp (under MEURI access outside of the clinical trial), an experimental drug GS5734, and a buffy coat of an Ebola survivor, and survived
  • Though the infant did have access to experimental therapeutics within 24 h of birth, access to other experimental compounds for her mother was denied, raising serious ethical concerns.

Ebola Virus Disease And Clinical Care Part III

Cdc.gov   DA: 11 PA: 50 MOZ Rank: 86

  • Clinical trials of convalescent plasma treatment for EVD are currently being conducted in Africa
  • ZMapp is a mix of three human-mouse monoclonal antibodies produced in tobacco plant cells
  • The antibodies bind to Ebola virus proteins and render the virus less able to infect cells in mammals
  • In NHPs, ZMapp completely protected rhesus

Regeneron’s REGN-EB3 And NIH’s MAb114 Show Promise For

Trialsitenews.com   DA: 17 PA: 50 MOZ Rank: 93

  • The independent data safety monitoring board decided to stop the trial after reviewing the interim mortality data from 499 patients
  • The trial was conducted in the DRC
  • The study was first initiated in 2018 with three treatment arms including 1) mAB114, 2) remdesivir and 3) ZMapp.

ZMapp Ebola Trial Starts In Liberia: Is It Too Late

Forbes.com   DA: 14 PA: 50 MOZ Rank: 91

  • LeafBio, the commercial arm of San Diego-based Mapp Biopharmaceutical, announced concomitantly that the FDA had approved their IND for this trial

Massachusetts General Hospital To Participate In Clinical

Massgeneral.org   DA: 19 PA: 50 MOZ Rank: 97

  • The ZMapp Expanded Access Protocol is a collaboration with the National Ebola Training and Education Center’s Special Pathogens Research Network (SPRN)
  • The SPRN is made up of representatives from the 10 RESPTCs across the United States
  • Ultimately, all 10 RESPTCs are expected to have the ZMapp

PALM Ebola Clinical Trial Stopped Early As Regeneron's

Bloomberg.com   DA: 17 PA: 50 MOZ Rank: 96

  • PALM Ebola Clinical Trial Stopped Early as Regeneron's REGN-EB3 Therapy Shows Superiority to ZMapp in Preventing Ebola Deaths PR Newswire TARRYTOWN, N.Y., Aug

New England Journal Of Medicine Publishes Results Of Ebola

Investor.regeneron.com   DA: 22 PA: 50 MOZ Rank: 20

  • The PAmoja TuLinde Maisha (PALM ["together save lives" in Kiswahili]) clinical trial was a randomized, multicenter, controlled trial initiated in 2018 to evaluate the safety and efficacy of three investigational Ebola virus disease therapies: mAb114, remdesivir and ZMapp
  • The trial protocol was amended after the World Health Organization (WHO

Ebola Drug ZMapp's Ready For African Testing

Nbcnews.com   DA: 15 PA: 50 MOZ Rank: 96

“As it is being filled in vials it is being shipped to West Africa in preparation for clinical trials." ZMapp consists of three lab-engineered immune system proteins called monoclonal antibodies.

NIH VideoCast

Videocast.nih.gov   DA: 17 PA: 12 MOZ Rank: 61

I will discuss issues related to designing and conducting treatment trials in outbreaks of Ebola and COVID based on my experience with three studies: Prevail II (the West African Ebola virus disease study of ZMapp), PALM (the Democratic Republic of the Congo Ebola virus disease study of ZMapp, mAb114, REGN-EB3 and remdesivir) and ACTT-1 (the

Regeneron, Ridgeback Ebola Meds Beat ZMapp, Prompting

Fiercebiotech.com   DA: 21 PA: 50 MOZ Rank: 17

In a world where clinical trials are often stopped due to patient deaths, safety issues or because the drug is likely to fail, an Ebola study in central Africa is ending early for the opposite reason.

Why Clinical Trials During Disease Outbreaks May Need A

Pennmedicine.org   DA: 20 PA: 50 MOZ Rank: 16

  • Why Clinical Trials During Disease Outbreaks May Need a New Approach
  • Scientists around the world are racing to develop vaccines and treatments for the novel coronavirus in an effort to halt the global COVID-19 pandemic
  • While recognizing the need for speed, the scientific community is committed to ensuring these treatments are safe and

Is ZMapp A Cure For The Ebola Epidemic

Cbsnews.com   DA: 15 PA: 50 MOZ Rank: 100

A randomized controlled trial in people -- the only way to thoroughly test the drug -- has yet to be conducted, which is why the usefulness of ZMapp is still up for debate.

Ebola: Experimental Drug ZMapp Is '100% Effective' In

Bbc.com   DA: 11 PA: 21 MOZ Rank: 68

  • The only clinical trial data on the experimental Ebola drug ZMapp shows it is 100% effective in monkey studies, even in later stages of the infection
  • The researchers, publishing their data

Regeneron Gets FDA Priority Review For Ebola Sibling Of

Fiercebiotech.com   DA: 21 PA: 50 MOZ Rank: 13

  • REGN-EB3 was one of two drugs to outperform ZMapp in the Ebola clinical trial
  • The drug that failed to move the needle was remdesivir, the Gilead antiviral that is …

PREVAIL Ebola Treatment Study Published In The New England

Lr.usembassy.gov   DA: 16 PA: 50 MOZ Rank: 12

Monrovia, October 13, 2016 – Results from the PREVAIL II clinical trial of ZMapp, an experimental treatment for Ebola virus disease (EVD), have been published by an international research team in the October 13 th issue of the The New England Journal of Medicine.Overall, ZMapp was safe and well-tolerated, and when delivered along with the best available standard of care, may have …

Lessons From COVID-19 Clinical Trials

Givethembreadandcircuses.com   DA: 28 PA: 39 MOZ Rank: 11

  • Is ZMapp available in significant quantities for use in Liberia
  • Liberia will give expedited review and approval for clinical trials with the antibody
  • I know I can work with researchers at Hopkins like Dr
  • Moss and the rest of the folks to jump start this
  • Even thought the safety and efficacy is not confirmed, Liberians are willing to sign

Ebola Drug ZMapp's Development Delayed By Pentagon Agency

Bloomberg.com   DA: 17 PA: 50 MOZ Rank: 10

  • Barda now has given Mapp Biopharmaceutical a $25 million contract to start clinical trials with ZMapp
  • This is encouraging, but it hasn’t fixed the problem
  • The Pentagon and the HHS have a …

The Ebola Clinical Trials: A Precedent For Research Ethics

Jme.bmj.com   DA: 11 PA: 15 MOZ Rank: 67

  • The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis
  • This unprecedented effort was supported by the recommendations of an ad hoc ethics panel convened in August 2014 by the WHO
  • By considering why and on what conditions the

WHO R&D Blueprint Ad-hoc Expert Consultation On Clinical

Who.int   DA: 11 PA: 50 MOZ Rank: 8

  • 4) Preclinical safety profile supporting safe clinical administration at doses potentially active against Ebola and Marburg virus infections
  • 5) Clinical safety profile from > 100 human subjects dosed with intravenous remdesivir supports the clinical dosing regimen recommended for the treatment of Ebola

The Response To Covid-19 Is Critical. It's Also Making

Statnews.com   DA: 16 PA: 50 MOZ Rank: 7

  • The response to Covid-19 is critical
  • It's also making clinical trials harder
  • Efforts to beat back the coronavirus are critical
  • They’re also making clinical trials harder

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